Lonzeal Pharmaceuticals Co., Ltd.

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Lonzeal Pharmaceuticals Co., Ltd.

Country:China (Mainland)

Business Type:Trading Company

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  • Mr.Cai
    Tel: +86-13381011962

  • Fax: +86-10-8217 6289
  • URL: http://www.lonzeal.com
  • Province/state: Beijing
  • City: Beijing
  • Street:RM 801, Yue MOMA, No. 26 Anningzhuang Rd. Haidian District, Beijing, China
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in stock Tenofovir TDF supplierTop quality of 202138-50-9

in stock Tenofovir TDF supplierTop quality of 202138-50-9 CAS NO.202138-50-9

  • Product Details

Keywords

  • TDF Tenofovir in stock
  • Tenofovir TDF supplier
  • Top quality of 202138-50-9

Quick Details

  • ProName: in stock Tenofovir TDF supplierTop qua...
  • CasNo: 202138-50-9
  • Molecular Formula: C23H34N5O14P
  • Appearance: White to off-white crystalline powder
  • Application: HIV, HBV
  • DeliveryTime: 10 days after ordering
  • PackAge: Two-layer LDPE bag and All Paper Drum
  • Port: Any port in China
  • ProductionCapacity: 200 Metric Ton/Year
  • Purity: 98.0%~102.0% (on anhydrous basis)
  • Storage: 2~8°C.
  • Transportation: as per request
  • LimitNum: 1 Kilogram

Superiority

 in stock Tenofovir TDF supplierTop quality of 202138-50-9

LONZEAL Pharmaceuticals was founded in 2006 and has become a leading manufacturing company covering finished formulation, active pharmaceutical ingredients and advanced intermediates, where ICH guidelines have been strictly applied in the whole chain of R&D, manufacturing process and quality management.

LONZEAL is taking attentiveness and profession to build high quality products, and contributing to health and beautiful life for everyone in the world. The products and manufacturing site of Lonzeal have been approved and inspected by stringent drug authorities such as USFDA, WHO, China NMPA, Brazil ANVISIA and India DCGI, based on which, we have been supplying to esteemed customers globally in the past 15 years with regulatory compliance and good quality.


 

 

Details

Fumaric acid tinofovir is a nucleotide-like antiviral drug developed and marketed by Gilead Corporation of the United States, approved by the United States FDA in 2001 for the treatment of human immunodeficiency virus (humanimmunodeficievirus, HIV) infection. Launched in the European Union in 2002, it is approved for treatment of HIV-1 and chronic hepatitis B. Fumaric acid tinofovirate as a nucleotide reverse transcriptase inhibitor, is an oral open-loop nucleotide phosphate predicate, oral absorption quickly converted to novovir and play a pharmaceutical effect. Due to its high bioavailability, precise efficacy and well-tolerated nature, TDF is now the recommended first-line anti-HIV drug with the highest sales. The patent literature reports on the synthesis method of Fumaric acid tinofovir, but there are some intermediate impurities, low optical purity, difficult operation, low yield, fumaric acid content is not qualified and not suitable for industrial production and so on.
Tinofovir is tinofovir diisopropyl methyl esters Yanhuso acid, is a ester precursor of Tinofove, is a ringless 5'-monophosphate adenosine analogue, with broad-spectrum antiviral action, can inhibit HIV-1, HIV-2 reverse transcriptase and HBV polymerase, thereby inhibiting viral replication. After oral administration, TDF hydrolyzes to tinofovir, which is processed by cell kinase phosphate into the pharmacologically active metabolite tinofovir diphosphate, which competes with 5'-triphosphate deoxydoxydenate to participate in the synthesis of viral DNA, which is blocked by the lack of 3'-OH DNA extension, thus inhibiting virus replication.

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Lonzeal Pharmaceuticals Co., Ltd.Tel:+86-13381011962 Fax:+86-10-8217 6289  Email:marketing@lonzeal.com info@lonzeal.com
 Address:RM 801, Yue MOMA, No. 26 Anningzhuang Rd. Haidian District, Beijing, China