TDF manufacturer 202138-50-9 with fast delivery 202138-50-9 Tenofovir Disoproxil Fumarate TDF

Product information "Tenofovir Disoproxil (fumarate)"

Tenofovir disoproxil is a prodrug of the acyclic nucleoside phosphonate, tenofovir (Cay-13874). Tenofovir is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase. Due to its rapid intracellular uptake, the anti-HIV activity of tenofovir disoproxil is reportedly >100-fold greater than that of the negatively charged tenofovir in a T cell line and primary blood lymphocytes. Formal Name: (5-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-2,4,6,8-tetraoxa-5-phosphanonanedioic acid, 1,9-bis(1-methylethyl) ester 5-oxide, (2E)-2-butenedioate. CAS Number: 202138-50-9. Synonyms: Bis(POC)-PMPA. Molecular Formula: C19H30N5O10P . C4H4O4. Formula Weight: 635.5. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 16 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml, DMSO: 14 mg/ml, Ethanol: 5 mg/ml. lambdamax: 209, 260 nm. SMILES: O=P(OCOC(OC(C)C)=O)(OCOC(OC(C)C)=O)CO[C@H](C)CN1C=NC2=C(N)N=CN=C21.O=C(O)/C=C/C(O)=O. InChi Code: InChI=1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24,5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22),1-2H,(H,5,6)(H,7,8)/b,2-1+/t14-,/m1./s1. InChi Key: VCMJCVGFSROFHV-WZGZYPNHSA-N.

LONZEAL Pharmaceuticals was founded in 2006 and has become a leading manufacturing company covering finished formulation, active pharmaceutical ingredients and advanced intermediates, where ICH guidelines have been strictly applied in the whole chain of R&D, manufacturing process and quality management.

LONZEAL is taking attentiveness and profession to build high quality products, and contributing to health and beautiful life for everyone in the world. The products and manufacturing site of Lonzeal have been approved and inspected by stringent drug authorities such as USFDA, WHO, China NMPA, Brazil ANVISIA and India DCGI, based on which, we have been supplying to esteemed customers globally in the past 15 years with regulatory compliance and good quality.

We have manufacturing site located in Hebei National Biomedical Industrial Zone, FPPs and APIs R&D Center of in Shijiazhuang Hi-tech Development Park, and the commercial office in Beijing, China.

Our current main products cover anti-virus, anti-depression and anti-neuropathic pain areas. Lonzeal has become one of the key manufacturers in the global supply of anti-HIV drugs and is providing support to the treatment need of over 4 Million patients each year worldwide.

Tenofovir dipivoxil fumarate, western name. Common dosage forms are tablets and oral powder. Used for HIV infection in children and adults over 2 years old. Chronic hepatitis B virus infection in children and adults over 12 years of age.

Our advantage:

1. Deeply cultivated in chemical foreign trade for many years, rich industry experience with fast delivery

2. Direct sales by chemical raw material manufacturers, low prices

3.Excellent scientific research team to ensure product quality and purity

4.Processing and production in large factories, realizing fast shipment