China (Mainland)
Supply 1392275-56-7 Tenofovir Alafenamide Hemifumarate TAF in stock with low price CAS NO.1392275-56-7
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Product Details
Keywords
- Tenofovir Alafenamide Hemifumarate TAF in stock
- Supply 1392275-56-7
- Tenofovir Alafenamide Hemifumarate TAF with low price
Quick Details
- ProName: Supply 1392275-56-7 Tenofovir Alafenam...
- CasNo: 1392275-56-7
- Molecular Formula: C21H29O5N6P·1/2(C4H4O4)
- Appearance: White to off white powder.
- Application: HIV, HBV
- DeliveryTime: 10 days after ordering
- PackAge: Two-layer LDPE bag and All Paper Barre...
- Port: Any port in China
- ProductionCapacity: 10 Metric Ton/Year
- Purity: 98.0%~102.0% (on the anhydrous basis)
- Storage: 2~8°C
- Transportation: as per request
- LimitNum: 1 Kilogram
Superiority
Supply 1392275-56-7 Tenofovir Alafenamide Hemifumarate TAF in stock with low price
An overview of the
Gilead's new drug, Vemlidy (Tenofovir alafialamine fumarate, 25mg, qD), was approved by the U.S. FDA to compensate for chronic hepatitis B virus infection in patients with liver disease. Vemlidy is an innovation of targeting drug tenofovir ago, with previous products 300 mg of Viread (tenofovir ester of fumaric acid salt, tenofovirdisoproxilfumarate), compared to only need less than one over ten of the dose can obtain similar antiviral activity. Clinical data showed that Vemlidy had better plasma stability and was able to deliver tenofovir to hepatocytes more effectively. Because of the lower dose, Vemlidy can improve the safety risk of kidney and bone in patients.
role
Tenofovir alafenamide (TAF), an oral nucleoside transcriptase inhibitor developed by Gilead, is another prodrug of tenofovir disoproxil fumarate (TDF), developed for hepatitis B virus infection (HBV) and acquired immune syndrome (HIV).
Use Tenofovir alafenamide fumarate can be used as catalyst in solvent, alkylation, esterification and polymerization reactions. 99% of the products are mainly used in medicine, 70% of the products are mainly used in electroplating industry. Nutritional drugs, combined with a low-protein diet, are the core drugs for the prevention and treatment of damage caused by protein metabolism disorder caused by chronic renal insufficiency, chronic renal insufficiency and wasting malnutrition.
LONZEAL Pharmaceuticals was founded in 2006 and has become a leading manufacturing company covering finished formulation, active pharmaceutical ingredients and advanced intermediates, where ICH guidelines have been strictly applied in the whole chain of R&D, manufacturing process and quality management.
LONZEAL is taking attentiveness and profession to build high quality products, and contributing to health and beautiful life for everyone in the world. The products and manufacturing site of Lonzeal have been approved and inspected by stringent drug authorities such as USFDA, WHO, China NMPA, Brazil ANVISIA and India DCGI, based on which, we have been supplying to esteemed customers globally in the past 15 years with regulatory compliance and good quality.
We have manufacturing site located in Hebei National Biomedical Industrial Zone, FPPs and APIs R&D Center of in Shijiazhuang Hi-tech Development Park, and the commercial office in Beijing, China.
Our current main products cover anti-virus, anti-depression and anti-neuropathic pain areas. Lonzeal has become one of the key manufacturers in the global supply of anti-HIV drugs and is providing support to the treatment need of over 4 Million patients each year worldwide.
LONZEAL is taking attentiveness and profession to build high quality products, and contributing to health and beautiful life for everyone in the world. The products and manufacturing site of Lonzeal have been approved and inspected by stringent drug authorities such as USFDA, WHO, China NMPA, Brazil ANVISIA and India DCGI, based on which, we have been supplying to esteemed customers globally in the past 15 years with regulatory compliance and good quality.
We have manufacturing site located in Hebei National Biomedical Industrial Zone, FPPs and APIs R&D Center of in Shijiazhuang Hi-tech Development Park, and the commercial office in Beijing, China.
Our current main products cover anti-virus, anti-depression and anti-neuropathic pain areas. Lonzeal has become one of the key manufacturers in the global supply of anti-HIV drugs and is providing support to the treatment need of over 4 Million patients each year worldwide.
Details
Tenofovir alafenamide fumarate bioactivity
describe
Tenofovir Alafenamide Fumarate (GS-7340 Fumarate) is a precursor of Tenofovir, an HIV-1 nucleotide reverse transcriptase inhibitor.
Related categories
The signaling pathway >> is anti-infection of >> HIV
>> signaling pathway anti-infection >> reverse transcriptase
The research area is >> infection
target
HIV-1, NRTIs[1]
In vitro studies
Tenofovir alafenamide showed similar antiviral activity in all cell types, ranging from 5 to 7 nM, while CC50 in MT-4 and MT-2 cells ranged from 4.7 to 42 M, respectively. Antiviral activity of TAF was evaluated against A group of HIV-1 and HIV-2 isolates, including hiv-1 subtypes A to G, and N and O isolates. Overall, for the 29 primary hiv-1 isolates tested in PBMC, TAF EC50 ranged from 0.1 to 12nM with an average EC50 of 3.5nM, and AZT had an average EC50 of 11.8nM, used as an internal control. For HIV-2 isolates, the mean EC50 for TAF and AZT was 1.8 nM and 6.4 nM respectively [2].
In vivo study
Tenofovir Alafenamide Hemifumarate is an amide prodrug for Tenofovir, which has better oral bioavailability and increased plasma stability compared with Tenofovir disopexy Fumarate (TDF) [1].
Physical and chemical properties of Tenofovir alafenamide fumarate
Molecular formula: C25H33N6O9P
Molecular weight: 592.538
Precise quality: 592.204651
PSA: 227.89000
LogP: 3.65680
English nickname
Tenofovir alafenamide fumarate, 1:1
TAF
GS-7340 fumarate
Isopropyl N-[(S)-({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}methyl)(phenoxy)phosphoryl]-L-alaninate (2E)-2-butenedioate (1:1)
L-Alanine, N-[(S)-[(1S)-[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (1:1)
Tenofovir alafenamide fumarate1:1
GS-7340 (fumarate)