China (Mainland)
Buy High quality of 1392275-56-7 Tenofovir Alafenamide Hemifumarate TAF manufacturer CAS NO.1392275-56-7
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Product Details
Keywords
- Buy 1392275-56-7
- High quality of Tenofovir Alafenamide Hemifumarate TAF
- Tenofovir Alafenamide Hemifumarate TAF manufacturer
Quick Details
- ProName: Buy High quality of 1392275-56-7 Tenof...
- CasNo: 1392275-56-7
- Molecular Formula: C21H29O5N6P·1/2(C4H4O4)
- Appearance: White to off white powder.
- Application: HIV, HBV
- DeliveryTime: 10 days after ordering
- PackAge: Two-layer LDPE bag and All Paper Barre...
- Port: Any port in China
- ProductionCapacity: 10 Metric Ton/Year
- Purity: 98.0%~102.0% (on the anhydrous basis)
- Storage: 2~8°C
- Transportation: as per request
- LimitNum: 1 Kilogram
Superiority
Buy High quality of 1392275-56-7 Tenofovir Alafenamide Hemifumarate TAF manufacturer
English synonyms:
L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-,1-methylethylester,(2E)-2-butenedioate(2:1); N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine1-methylethylester(2E)-2-butenedioate(2:1); GS-734Chemicalbook0(hemifumarate); TENOFOVIRALAFENAMIDEHEMIFUMARATE(GS-7340HEMIFUMARATE); Tenofovirlevamideaminefumarate; GS7340(TenofovirAlafenamideFumarate); (Tenofoviralafenamide:fumarate=2:1);
Anti-hivcas Number :1392275-56-7
Molecular formula :2(C21H29N6O5P).C4H4O4
Molecular weight :0
EINECS No. :805-448-8 Antiviral drugs for medicine; Antiviral; API
Mol file: MolFile
LONZEAL Pharmaceuticals was founded in 2006 and has become a leading manufacturing company covering finished formulation, active pharmaceutical ingredients and advanced intermediates, where ICH guidelines have been strictly applied in the whole chain of R&D, manufacturing process and quality management.
LONZEAL is taking attentiveness and profession to build high quality products, and contributing to health and beautiful life for everyone in the world. The products and manufacturing site of Lonzeal have been approved and inspected by stringent drug authorities such as USFDA, WHO, China NMPA, Brazil ANVISIA and India DCGI, based on which, we have been supplying to esteemed customers globally in the past 15 years with regulatory compliance and good quality.
We have manufacturing site located in Hebei National Biomedical Industrial Zone, FPPs and APIs R&D Center of in Shijiazhuang Hi-tech Development Park, and the commercial office in Beijing, China.
Our current main products cover anti-virus, anti-depression and anti-neuropathic pain areas. Lonzeal has become one of the key manufacturers in the global supply of anti-HIV drugs and is providing support to the treatment need of over 4 Million patients each year worldwide.
LONZEAL is taking attentiveness and profession to build high quality products, and contributing to health and beautiful life for everyone in the world. The products and manufacturing site of Lonzeal have been approved and inspected by stringent drug authorities such as USFDA, WHO, China NMPA, Brazil ANVISIA and India DCGI, based on which, we have been supplying to esteemed customers globally in the past 15 years with regulatory compliance and good quality.
We have manufacturing site located in Hebei National Biomedical Industrial Zone, FPPs and APIs R&D Center of in Shijiazhuang Hi-tech Development Park, and the commercial office in Beijing, China.
Our current main products cover anti-virus, anti-depression and anti-neuropathic pain areas. Lonzeal has become one of the key manufacturers in the global supply of anti-HIV drugs and is providing support to the treatment need of over 4 Million patients each year worldwide.
Details
role
Tenofovir alafenamide (TAF), an oral nucleoside transcriptase inhibitor developed by Gilead, is another prodrug of tenofovir disoproxil fumarate (TDF), developed for hepatitis B virus infection (HBV) and acquired immune syndrome (HIV).
use
Tenofovir alafine fumarate can be used as a solvent, catalyst for alkylation, esterification and polymerization reactions. 99% of the products are mainly used in medicine, 70% of the products are mainly used in electroplating industry. Nutritional drugs, combined with a low-protein diet, are the core drugs for the prevention and treatment of damage caused by protein metabolism disorder caused by chronic renal insufficiency, chronic renal insufficiency and wasting malnutrition.
Treatment of chronic hepatitis B
Tenofoviralafenamide (TAF) is a new nucleotide reverse transcriptase inhibitor developed by Gilead for the treatment of chronic hepatitis B virus infection and compensatory liver disease. For Norfolk WeiYi phenol amine is tenofovir (tenofovir, TFV) prior to the oral medicine, listed drug tenofovir ester (tenofovirdisoproxilfumarate, TDF) modified, relative to the TDF, TAF clinical medication doses are smaller, and easier to enter cells play effect, more antiviral efficacy and reduce adverse reaction. Tenofovir alafine was approved by the FDA on November 11, 2016. Chemicalbook10 is intended for the treatment of adult patients with chronic hepatitis B.
It was approved to market by PMDA on December 19, 2016 and EMA on September 19, 2017, becoming the first hepatitis B drug approved to market in Europe in the past 10 years.
Prior to this, Gilead has developed three compounds that have been approved for use in the treatment of HIV infection, all of which are based on tenofovir alafenamide, as follows: In November 2015, Gilead developed a four-in-one compound monocle, Genvoya, approved for sale in the United States and the European Union, consisting of fixed doses of 150mg Elvitegravir (E), 150mg cobicistat (C), 200mg Emtricitabine (F) and 10mgTAF.
On March 1, 2016, a new drug was marketed as a compound in the United States under the trade name Odefsey and contains 25mg of ripivirine (R), 200mg of emtritabine and 25mg of tenofovir alafolamine.
On April 4, 2016, the new drug, marketed as a compound in the United States under the name Descovy, contained 200mg of emtricitabine and 25mg of tenofovir alafirenamide.