China (Mainland)
Lamivudine factory 134678-17-4 cheapTop quality of Lamivudine CAS NO.134678-17-4
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Product Details
Keywords
- Lamivudine factory
- 134678-17-4 cheap
- Top quality of Lamivudine
Quick Details
- ProName: Lamivudine factory 134678-17-4 cheapTo...
- CasNo: 134678-17-4
- Molecular Formula: C8H11N3O3S
- Appearance: White or almost white crystalline soli...
- Application: HIV, HBV
- DeliveryTime: 10 days after ordering
- PackAge: Two-layer LDPE bag and All Paper Drum
- Port: Any port in China
- ProductionCapacity: 500 Metric Ton/Year
- Purity: 98.0%~102.0%
- Storage: Below 30°C.
- Transportation: as per request
- LimitNum: 1 Kilogram
- Grade: Pharma Grade
Superiority
Lamivudine factory 134678-17-4 cheapTop quality of Lamivudine
[CAS] 17-134678-4
[ molecular formula]C8H11N3O3S
[MDL no.] MFCD00869739
[Molecular weight] 229.26
[MOL File]
134678-17-4.mol
[Category] Drugs: Disease-resistant microbial drugs: antiviral drugs
[Appearance properties] White solid obtained from methanol - ethyl acetate. [a]D21-132°(C=1.08, methanol). Or from boiling ethanol crystallization, melting point 160 ~ 162℃. [a]D21-135°(C=0.38, methanol).
[Melting point] 177 °C
[refractive index] -142 ° (C=1, MeOH)
If you store it like ice, like ice
[Merck] 5352
[usage]
1. Antiviral drugs for the treatment of liver and gallbladder diseases
2. Antiviral drugs for hepatitis B.
3. Drugs for hepatobiliary diseases.
LONZEAL Pharmaceuticals was founded in 2006 and has become a leading manufacturing company covering finished formulation, active pharmaceutical ingredients and advanced intermediates, where ICH guidelines have been strictly applied in the whole chain of R&D, manufacturing process and quality management.
LONZEAL is taking attentiveness and profession to build high quality products, and contributing to health and beautiful life for everyone in the world. The products and manufacturing site of Lonzeal have been approved and inspected by stringent drug authorities such as USFDA, WHO, China NMPA, Brazil ANVISIA and India DCGI, based on which, we have been supplying to esteemed customers globally in the past 15 years with regulatory compliance and good quality.
We have manufacturing site located in Hebei National Biomedical Industrial Zone, FPPs and APIs R&D Center of in Shijiazhuang Hi-tech Development Park, and the commercial office in Beijing, China.
Our current main products cover anti-virus, anti-depression and anti-neuropathic pain areas. Lonzeal has become one of the key manufacturers in the global supply of anti-HIV drugs and is providing support to the treatment need of over 4 Million patients each year worldwide.
LONZEAL is taking attentiveness and profession to build high quality products, and contributing to health and beautiful life for everyone in the world. The products and manufacturing site of Lonzeal have been approved and inspected by stringent drug authorities such as USFDA, WHO, China NMPA, Brazil ANVISIA and India DCGI, based on which, we have been supplying to esteemed customers globally in the past 15 years with regulatory compliance and good quality.
We have manufacturing site located in Hebei National Biomedical Industrial Zone, FPPs and APIs R&D Center of in Shijiazhuang Hi-tech Development Park, and the commercial office in Beijing, China.
Our current main products cover anti-virus, anti-depression and anti-neuropathic pain areas. Lonzeal has become one of the key manufacturers in the global supply of anti-HIV drugs and is providing support to the treatment need of over 4 Million patients each year worldwide.
Details
The preparation methods
For selective compounds (Ⅰ) 6 - O - sulfonic acid reaction, and then acetylated compounds (Ⅱ), yield of 96.7%. Compounds (Ⅱ) with acetic acid as solvent, acid and hydrogen bromide, 3 mol/L (45%, W/V) reaction, bromide compounds (Ⅲ), yield of 99%. Bromide (Ⅲ) and 3.3 moI. Ethyl xanthate potassium salt, reflux in acetone, thiosyncytic; Then hydrolyzed in methanol in ammonia, compounds (Ⅳ), the second step yield of 72%.
Compounds (Ⅳ) by column chromatography purification, as a crystalline solid.
Compounds (Ⅳ) with 1.4 mole of sodium periodate processing, in order to make 2, 3 - cis diol open loop; The aldehyde is then reduced with sodium borohydride and the diol is protected with ketone formation to obtain the compound (V) with a yield of 60%. Compound (V) silicon alkylation in order to protect the rest of the primary alcohol, to remove ketal, get compounds (Ⅵ), yield of 63%. Oxide compounds with four lead acetate (Ⅵ) of glycol, and then further by the shop two chromic acid pyridine salt oxidation, get compounds (Ⅶ), the oxidation method does not affect the sulphur.
Compounds (Ⅶ) with four acetic lead oxide, get compounds (Ⅷ), yield of 66% [in compounds (Ⅵ)]. Compounds (Ⅷ) and (Ⅸ), ethylene dichloride, using TMSOTf as a Lewis acid catalyst, condensation compound (X), yield of 64%.
There are also isomers of compound (X) in half the amount of compound (X) that can be separated by silica gel chromatography. The compound (X) was acetylated with ammonia - methanol in a yield of 73%; Lamivudine was obtained by desilication with ammonium tetrbutylfluoride in 75% yield.