147127-20-6 supplierfactory of 147127-20-6Tenofovir Intermediate - PMPA China Factory

Preparation

Dissolve diethyl phosphite, paraformaldehyde and triethylamine in toluene, react under the protection of nitrogen, and reflux. After the reaction is complete, it is cooled, and p-toluenesulfonyl chloride and triethylamine are slowly added to react to obtain diethyl p-toluenesulfonyloxymethylphosphonate. Under the protection of nitrogen, (S)-glycidol, 5% palladium-carbon, ethanol and sodium hydroxide aqueous solution are mixed for hydrogenation to obtain (R)-1,2-propanediol. The ethanol solution of diethyl carbonate and sodium ethoxide is added to react to obtain (R)-1,2-propylene glycol carbonate. Dissolve it with adenine, diethyl p-toluenesulfonyloxymethylphosphonate and sodium hydroxide in dimethylformamide, and react to obtain (R)-9-[2-(diethylphosphonomethoxy) ) Propyl] Adenine. Dissolve it in acetonitrile, add bromotrimethylsilane to obtain crude tenofovir, and recrystallize to obtain pure product. Mix tenofovir, 1-methyl-2-pyrrolidone and triethylamine into chloromethyl propyl carbonate for reaction, and then acidify with fumaric acid to obtain tenofovir fumarate double pivaloyloxy group Methyl ester.

F AND Q

1. Are you a trading company or a factory?

We are a factory with our own trading company.

2. How do you control the quality?

Our factory is equipped with professional technicians for quality control, and external inspectors take samples for testing every 2 hours to ensure the quality of our production. 
We also accept BV, SGS or any other third party inspections.

3. How to start an order or payment?

After confirming the order, a proforma invoice will be sent first, with our bank information attached. 
Payment by T/T, .

4. How to confirm product quality before placing an order?
  
You can get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples.
  
You can send us your product specifications and requirements, and we will manufacture products according to your requirements.

5. Can I get some samples?

Yes, we can provide free samples, but the freight is paid by our customers.

6. How long is the delivery time?

We ship small orders within 3 days, and bulk orders within 7-10 days.

7. Where is your factory? 
How to visit the factory?

Our factory is located in Hebei, China.

8. How long is the delivery time?

We ship small orders within 3 days, and bulk orders within 7-10 days.

9. How do you handle quality complaints?
  
First, our quality control reduces quality problems to close to zero. 
If it is a real quality problem caused by us, we will replace it for you free of charge or refund your loss.