147127-20-6 discount147127-20-6 in bulk pricemanufacturer of  Tenofovir Intermediate - PMPA

LONZEAL Pharmaceuticals was founded in 2006 and has become a leading manufacturing company covering finished formulation, active pharmaceutical ingredients and advanced intermediates, where ICH guidelines have been strictly applied in the whole chain of R&D, manufacturing process and quality management.

LONZEAL is taking attentiveness and profession to build high quality products, and contributing to health and beautiful life for everyone in the world. The products and manufacturing site of Lonzeal have been approved and inspected by stringent drug authorities such as USFDA, WHO, China NMPA, Brazil ANVISIA and India DCGI, based on which, we have been supplying to esteemed customers globally in the past 15 years with regulatory compliance and good quality.

We have manufacturing site located in Hebei National Biomedical Industrial Zone, FPPs and APIs R&D Center of in Shijiazhuang Hi-tech Development Park, and the commercial office in Beijing, China.

Our current main products cover anti-virus, anti-depression and anti-neuropathic pain areas. Lonzeal has become one of the key manufacturers in the global supply of anti-HIV drugs and is providing support to the treatment need of over 4 Million patients each year worldwide.

Lonzeal Pharmaceuticals is drug manufacturer with China/WHO/FDA/ANVISA GMP certificates. We supply pharmaceutical products to esteemed customers globally with high quality, competitive price and good service.

Tenofovir is almost not absorbed through the gastrointestinal tract, so it undergoes esterification and salt formation to become tenofovir disoproxil fumarate. Tenofovir dipivoxil is water-soluble and can be rapidly absorbed and degraded into the active substance tenofovir, and then tenofovir is converted into the active metabolite tenofovir bisphosphate. Tenofovirda blood peak value within 1 to 2 hours after administration. 
The bioavailability of tenofovir can be increased by about 40% when taken with food. The intracellular half-life of tenofovir bisphosphate is about 10 hours, and it can be administered once a day. Since the drug is not metabolized by the CYP450 enzyme system, the possibility of interaction with other drugs caused by the enzyme is very small. The drug is mainly excreted through glomerular filtration and active tubule transport system, and about 70% to 80% is excreted through urine in its original form.

Indications

It is used to treat HIV and HBV infection. 
This product and other reverse transcriptase inhibitors are used in the treatment of HIV-1 infection and hepatitis B.